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Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

BACKGROUND: UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. GNE is the only human protein that contains a kinase domai...

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Detalles Bibliográficos
Autores principales:	Tong, Yufeng, Tempel, Wolfram, Nedyalkova, Lyudmila, MacKenzie, Farrell, Park, Hee-Won
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742894/ https://www.ncbi.nlm.nih.gov/pubmed/19841673 http://dx.doi.org/10.1371/journal.pone.0007165

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