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Igλ(+) B cell development but not Igκ editing depends on NF-κB signals
By genetically ablating IκB kinase (IKK)-mediated NF-κB activation in the B cell lineage, and by analyzing a mouse mutant in which Igλ(+) B cells are generated in the absence of rearrangements in Igk, we define two distinct, consecutive phases of early B cell development that differ in their depende...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742984/ https://www.ncbi.nlm.nih.gov/pubmed/19412180 http://dx.doi.org/10.1038/ni.1732 |