siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication

A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological ho...

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Detalles Bibliográficos
Autores principales: Kok, Kin-Hang, Lei, Ting, Jin, Dong-Yan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743632/
https://www.ncbi.nlm.nih.gov/pubmed/19712452
http://dx.doi.org/10.1186/1742-4690-6-78
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author Kok, Kin-Hang
Lei, Ting
Jin, Dong-Yan
author_facet Kok, Kin-Hang
Lei, Ting
Jin, Dong-Yan
author_sort Kok, Kin-Hang
collection PubMed
description A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions.
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spelling pubmed-27436322009-09-15 siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication Kok, Kin-Hang Lei, Ting Jin, Dong-Yan Retrovirology Commentary A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions. BioMed Central 2009-08-27 /pmc/articles/PMC2743632/ /pubmed/19712452 http://dx.doi.org/10.1186/1742-4690-6-78 Text en Copyright © 2009 Kok et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Kok, Kin-Hang
Lei, Ting
Jin, Dong-Yan
siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title_full siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title_fullStr siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title_full_unstemmed siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title_short siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
title_sort sirna and shrna screens advance key understanding of host factors required for hiv-1 replication
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743632/
https://www.ncbi.nlm.nih.gov/pubmed/19712452
http://dx.doi.org/10.1186/1742-4690-6-78
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