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Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging

BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovas...

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Autores principales: Yousef, Zaheer R, Foley, Paul WX, Khadjooi, Kayvan, Chalil, Shajil, Sandman, Harald, Mohammed, Noor UH, Leyva, Francisco
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743643/
https://www.ncbi.nlm.nih.gov/pubmed/19664240
http://dx.doi.org/10.1186/1471-2261-9-37
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author Yousef, Zaheer R
Foley, Paul WX
Khadjooi, Kayvan
Chalil, Shajil
Sandman, Harald
Mohammed, Noor UH
Leyva, Francisco
author_facet Yousef, Zaheer R
Foley, Paul WX
Khadjooi, Kayvan
Chalil, Shajil
Sandman, Harald
Mohammed, Noor UH
Leyva, Francisco
author_sort Yousef, Zaheer R
collection PubMed
description BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction.
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spelling pubmed-27436432009-09-15 Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging Yousef, Zaheer R Foley, Paul WX Khadjooi, Kayvan Chalil, Shajil Sandman, Harald Mohammed, Noor UH Leyva, Francisco BMC Cardiovasc Disord Research Article BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction. BioMed Central 2009-08-09 /pmc/articles/PMC2743643/ /pubmed/19664240 http://dx.doi.org/10.1186/1471-2261-9-37 Text en Copyright © 2009 Yousef et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yousef, Zaheer R
Foley, Paul WX
Khadjooi, Kayvan
Chalil, Shajil
Sandman, Harald
Mohammed, Noor UH
Leyva, Francisco
Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title_full Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title_fullStr Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title_full_unstemmed Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title_short Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
title_sort left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743643/
https://www.ncbi.nlm.nih.gov/pubmed/19664240
http://dx.doi.org/10.1186/1471-2261-9-37
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