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Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovas...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743643/ https://www.ncbi.nlm.nih.gov/pubmed/19664240 http://dx.doi.org/10.1186/1471-2261-9-37 |
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author | Yousef, Zaheer R Foley, Paul WX Khadjooi, Kayvan Chalil, Shajil Sandman, Harald Mohammed, Noor UH Leyva, Francisco |
author_facet | Yousef, Zaheer R Foley, Paul WX Khadjooi, Kayvan Chalil, Shajil Sandman, Harald Mohammed, Noor UH Leyva, Francisco |
author_sort | Yousef, Zaheer R |
collection | PubMed |
description | BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction. |
format | Text |
id | pubmed-2743643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27436432009-09-15 Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging Yousef, Zaheer R Foley, Paul WX Khadjooi, Kayvan Chalil, Shajil Sandman, Harald Mohammed, Noor UH Leyva, Francisco BMC Cardiovasc Disord Research Article BACKGROUND: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 ± 2.3 yrs (mean ± SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction. BioMed Central 2009-08-09 /pmc/articles/PMC2743643/ /pubmed/19664240 http://dx.doi.org/10.1186/1471-2261-9-37 Text en Copyright © 2009 Yousef et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yousef, Zaheer R Foley, Paul WX Khadjooi, Kayvan Chalil, Shajil Sandman, Harald Mohammed, Noor UH Leyva, Francisco Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title | Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title_full | Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title_fullStr | Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title_full_unstemmed | Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title_short | Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
title_sort | left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743643/ https://www.ncbi.nlm.nih.gov/pubmed/19664240 http://dx.doi.org/10.1186/1471-2261-9-37 |
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