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Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

Brr2 is a DExD/H-box helicase responsible for U4/U6 unwinding during spliceosomal activation. Brr2 contains two helicase-like domains, each of which is followed by a Sec63 domain with unknown function. We determined the crystal structure of the second Sec63 domain, which unexpectedly resembles domai...

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Detalles Bibliográficos
Autores principales:	Zhang, Lingdi, Xu, Tao, Maeder, Corina, Bud, Laura-Oana, Shanks, James, Nix, Jay, Guthrie, Christine, Pleiss, Jeffrey A., Zhao, Rui
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743687/ https://www.ncbi.nlm.nih.gov/pubmed/19525970 http://dx.doi.org/10.1038/nsmb.1625

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