Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the hippocampus

Inhibition of phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP (cAMP), increases phosphorylation of cAMP-response element binding protein (pCREB) and hippocampal neurogenesis, and produces antidepressant-like effects on behavior; however, causal links among these hav...

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Detalles Bibliográficos
Autores principales: Li, Yun-Feng, Huang, Ying, Amsdell, Simon L., Xiao, Lan, O'Donnell, James M., Zhang, Han-Ting
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743762/
https://www.ncbi.nlm.nih.gov/pubmed/19516250
http://dx.doi.org/10.1038/npp.2009.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743762/
https://www.ncbi.nlm.nih.gov/pubmed/19516250
http://dx.doi.org/10.1038/npp.2009.66

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