An Evolutionary Perspective of Animal MicroRNAs and Their Targets

MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRN...

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Detalles Bibliográficos
Autores principales: Shomron, Noam, Golan, David, Hornstein, Eran
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743850/
https://www.ncbi.nlm.nih.gov/pubmed/19759918
http://dx.doi.org/10.1155/2009/594738
Descripción
Sumario:MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs.

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