An Evolutionary Perspective of Animal MicroRNAs and Their Targets

MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRN...

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Detalles Bibliográficos
Autores principales: Shomron, Noam, Golan, David, Hornstein, Eran
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743850/
https://www.ncbi.nlm.nih.gov/pubmed/19759918
http://dx.doi.org/10.1155/2009/594738
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author Shomron, Noam
Golan, David
Hornstein, Eran
author_facet Shomron, Noam
Golan, David
Hornstein, Eran
author_sort Shomron, Noam
collection PubMed
description MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs.
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spelling pubmed-27438502009-09-16 An Evolutionary Perspective of Animal MicroRNAs and Their Targets Shomron, Noam Golan, David Hornstein, Eran J Biomed Biotechnol Review Article MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs. Hindawi Publishing Corporation 2009 2009-09-14 /pmc/articles/PMC2743850/ /pubmed/19759918 http://dx.doi.org/10.1155/2009/594738 Text en Copyright © 2009 Noam Shomron et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shomron, Noam
Golan, David
Hornstein, Eran
An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title_full An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title_fullStr An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title_full_unstemmed An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title_short An Evolutionary Perspective of Animal MicroRNAs and Their Targets
title_sort evolutionary perspective of animal micrornas and their targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743850/
https://www.ncbi.nlm.nih.gov/pubmed/19759918
http://dx.doi.org/10.1155/2009/594738
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