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Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria
BACKGROUND: Dual epidemics of the malaria parasite Plasmodium and HIV-1 in sub-Saharan Africa and Asia present a significant risk for co-infection in these overlapping endemic regions. Recent studies of HIV/Plasmodium falciparum co-infection have reported significant interactions of these pathogens,...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744481/ https://www.ncbi.nlm.nih.gov/pubmed/19774084 http://dx.doi.org/10.1371/journal.pone.0007139 |
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author | Koehler, Jeffrey W. Bolton, Michael Rollins, Amanda Snook, Kirsten deHaro, Eileen Henson, Elizabeth Rogers, Linda Martin, Louis N. Krogstad, Donald J. James, Mark A. Rice, Janet Davison, Billie Veazey, Ronald S. Prabhu, Ramesh Amedee, Angela M. Garry, Robert F. Cogswell, Frank B. |
author_facet | Koehler, Jeffrey W. Bolton, Michael Rollins, Amanda Snook, Kirsten deHaro, Eileen Henson, Elizabeth Rogers, Linda Martin, Louis N. Krogstad, Donald J. James, Mark A. Rice, Janet Davison, Billie Veazey, Ronald S. Prabhu, Ramesh Amedee, Angela M. Garry, Robert F. Cogswell, Frank B. |
author_sort | Koehler, Jeffrey W. |
collection | PubMed |
description | BACKGROUND: Dual epidemics of the malaria parasite Plasmodium and HIV-1 in sub-Saharan Africa and Asia present a significant risk for co-infection in these overlapping endemic regions. Recent studies of HIV/Plasmodium falciparum co-infection have reported significant interactions of these pathogens, including more rapid CD4+ T cell loss, increased viral load, increased immunosuppression, and increased episodes of clinical malaria. Here, we describe a novel rhesus macaque model for co-infection that supports and expands upon findings in human co-infection studies and can be used to identify interactions between these two pathogens. METHODOLOGY/PRINCIPAL FINDINGS: Five rhesus macaques were infected with P. cynomolgi and, following three parasite relapses, with SIV. Compared to macaques infected with SIV alone, co-infected animals had, as a group, decreased survival time and more rapid declines in markers for SIV progression, including peripheral CD4+ T cells and CD4+/CD8+ T cell ratios. The naïve CD4+ T cell pool of the co-infected animals was depleted more rapidly than animals infected with SIV alone. The co-infected animals also failed to generate proliferative responses to parasitemia by CD4+ and CD8+ T cells as well as B cells while also having a less robust anti-parasite and altered anti-SIV antibody response. CONCLUSIONS/SIGNIFICANCE: These data suggest that infection with both SIV and Plasmodium enhances SIV-induced disease progression and impairs the anti-Plasmodium immune response. These data support findings in HIV/Plasmodium co-infection studies. This animal model can be used to further define impacts of lentivirus and Plasmodium co-infection and guide public health and therapeutic interventions. |
format | Text |
id | pubmed-2744481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-27444812009-09-23 Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria Koehler, Jeffrey W. Bolton, Michael Rollins, Amanda Snook, Kirsten deHaro, Eileen Henson, Elizabeth Rogers, Linda Martin, Louis N. Krogstad, Donald J. James, Mark A. Rice, Janet Davison, Billie Veazey, Ronald S. Prabhu, Ramesh Amedee, Angela M. Garry, Robert F. Cogswell, Frank B. PLoS One Research Article BACKGROUND: Dual epidemics of the malaria parasite Plasmodium and HIV-1 in sub-Saharan Africa and Asia present a significant risk for co-infection in these overlapping endemic regions. Recent studies of HIV/Plasmodium falciparum co-infection have reported significant interactions of these pathogens, including more rapid CD4+ T cell loss, increased viral load, increased immunosuppression, and increased episodes of clinical malaria. Here, we describe a novel rhesus macaque model for co-infection that supports and expands upon findings in human co-infection studies and can be used to identify interactions between these two pathogens. METHODOLOGY/PRINCIPAL FINDINGS: Five rhesus macaques were infected with P. cynomolgi and, following three parasite relapses, with SIV. Compared to macaques infected with SIV alone, co-infected animals had, as a group, decreased survival time and more rapid declines in markers for SIV progression, including peripheral CD4+ T cells and CD4+/CD8+ T cell ratios. The naïve CD4+ T cell pool of the co-infected animals was depleted more rapidly than animals infected with SIV alone. The co-infected animals also failed to generate proliferative responses to parasitemia by CD4+ and CD8+ T cells as well as B cells while also having a less robust anti-parasite and altered anti-SIV antibody response. CONCLUSIONS/SIGNIFICANCE: These data suggest that infection with both SIV and Plasmodium enhances SIV-induced disease progression and impairs the anti-Plasmodium immune response. These data support findings in HIV/Plasmodium co-infection studies. This animal model can be used to further define impacts of lentivirus and Plasmodium co-infection and guide public health and therapeutic interventions. Public Library of Science 2009-09-23 /pmc/articles/PMC2744481/ /pubmed/19774084 http://dx.doi.org/10.1371/journal.pone.0007139 Text en Koehler et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Koehler, Jeffrey W. Bolton, Michael Rollins, Amanda Snook, Kirsten deHaro, Eileen Henson, Elizabeth Rogers, Linda Martin, Louis N. Krogstad, Donald J. James, Mark A. Rice, Janet Davison, Billie Veazey, Ronald S. Prabhu, Ramesh Amedee, Angela M. Garry, Robert F. Cogswell, Frank B. Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title | Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title_full | Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title_fullStr | Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title_full_unstemmed | Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title_short | Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi: An Animal Model for Coincident AIDS and Relapsing Malaria |
title_sort | altered immune responses in rhesus macaques co-infected with siv and plasmodium cynomolgi: an animal model for coincident aids and relapsing malaria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744481/ https://www.ncbi.nlm.nih.gov/pubmed/19774084 http://dx.doi.org/10.1371/journal.pone.0007139 |
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