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Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepre...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744677/ https://www.ncbi.nlm.nih.gov/pubmed/19732448 http://dx.doi.org/10.1186/1478-811X-7-21 |
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author | Harder, Thomas Sangani, Dhaval |
author_facet | Harder, Thomas Sangani, Dhaval |
author_sort | Harder, Thomas |
collection | PubMed |
description | Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. |
format | Text |
id | pubmed-2744677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27446772009-09-16 Plasma membrane rafts engaged in T cell signalling: new developments in an old concept Harder, Thomas Sangani, Dhaval Cell Commun Signal Review Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. BioMed Central 2009-09-04 /pmc/articles/PMC2744677/ /pubmed/19732448 http://dx.doi.org/10.1186/1478-811X-7-21 Text en Copyright © 2009 Harder and Sangani; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Harder, Thomas Sangani, Dhaval Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title_full | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title_fullStr | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title_full_unstemmed | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title_short | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
title_sort | plasma membrane rafts engaged in t cell signalling: new developments in an old concept |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744677/ https://www.ncbi.nlm.nih.gov/pubmed/19732448 http://dx.doi.org/10.1186/1478-811X-7-21 |
work_keys_str_mv | AT harderthomas plasmamembraneraftsengagedintcellsignallingnewdevelopmentsinanoldconcept AT sanganidhaval plasmamembraneraftsengagedintcellsignallingnewdevelopmentsinanoldconcept |