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Plasma membrane rafts engaged in T cell signalling: new developments in an old concept

Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepre...

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Detalles Bibliográficos
Autores principales: Harder, Thomas, Sangani, Dhaval
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744677/
https://www.ncbi.nlm.nih.gov/pubmed/19732448
http://dx.doi.org/10.1186/1478-811X-7-21
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author Harder, Thomas
Sangani, Dhaval
author_facet Harder, Thomas
Sangani, Dhaval
author_sort Harder, Thomas
collection PubMed
description Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane.
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spelling pubmed-27446772009-09-16 Plasma membrane rafts engaged in T cell signalling: new developments in an old concept Harder, Thomas Sangani, Dhaval Cell Commun Signal Review Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. BioMed Central 2009-09-04 /pmc/articles/PMC2744677/ /pubmed/19732448 http://dx.doi.org/10.1186/1478-811X-7-21 Text en Copyright © 2009 Harder and Sangani; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Harder, Thomas
Sangani, Dhaval
Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title_full Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title_fullStr Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title_full_unstemmed Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title_short Plasma membrane rafts engaged in T cell signalling: new developments in an old concept
title_sort plasma membrane rafts engaged in t cell signalling: new developments in an old concept
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744677/
https://www.ncbi.nlm.nih.gov/pubmed/19732448
http://dx.doi.org/10.1186/1478-811X-7-21
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