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"hCG priming" effect in controlled ovarian stimulation through a long protocol

BACKGROUND: Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa), a short-term pre-treatment with recombinant LH (rLH), prior to recombinant FSH (rFSH) administration, increases the number of small antral follicle prior to FSH stimulation and the yield of nor...

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Autores principales: Beretsos, Panagiotis, Partsinevelos, George A, Arabatzi, Eleni, Drakakis, Peter, Mavrogianni, Depy, Anagnostou, Elli, Stefanidis, Kostas, Antsaklis, Aris, Loutradis, Dimitris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744681/
https://www.ncbi.nlm.nih.gov/pubmed/19719843
http://dx.doi.org/10.1186/1477-7827-7-91
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author Beretsos, Panagiotis
Partsinevelos, George A
Arabatzi, Eleni
Drakakis, Peter
Mavrogianni, Depy
Anagnostou, Elli
Stefanidis, Kostas
Antsaklis, Aris
Loutradis, Dimitris
author_facet Beretsos, Panagiotis
Partsinevelos, George A
Arabatzi, Eleni
Drakakis, Peter
Mavrogianni, Depy
Anagnostou, Elli
Stefanidis, Kostas
Antsaklis, Aris
Loutradis, Dimitris
author_sort Beretsos, Panagiotis
collection PubMed
description BACKGROUND: Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa), a short-term pre-treatment with recombinant LH (rLH), prior to recombinant FSH (rFSH) administration, increases the number of small antral follicle prior to FSH stimulation and the yield of normally fertilized embryos. However, no data exist in the literature regarding the potential beneficial effect of "hCG priming" in controlled ovarian hyperstimulation (COH) through a long GnRH-a protocol, which binds the same receptor (LH/hCGR), though it is a much more potent compared to LH. The primary aims of this study were to assess the effect of short-term pre-rFSH administration of hCG in women entering an ICSI treatment cycle on follicular development, quality of oocytes and early embryo development. The secondary endpoints were to record the effects on endometrial quality and pregnancy rate. METHODS: Patients with a history of at least one previous unsuccessful ICSI cycle were randomly assigned into two groups to receive treatment with either a long protocol with rFSH (control group) or a long protocol with rFSH and pre-treatment with hCG (hCG group). In particular, in the latter group, a fixed 7 days course of 200 IU/day hCG was administered as soon as pituitary desensitization was confirmed. RESULTS: The mean number of oocytes retrieved was not significantly different between the two treatment groups, although the percentage of mature oocytes tended to be higher but not significantly different in hCG-treated patients. The percentage of patients with more than one grade 3 embryos was higher in the pre-treatment group, which also showed a higher pregnancy rate. CONCLUSION: All the above clinical observations, in conjunction with previous data, suggest a point towards a beneficial "hCG priming" effect in controlled ovarian hyperstimulation through a long GnRH-a down-regulation protocol, particularly in patients with previous ART failures.
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spelling pubmed-27446812009-09-16 "hCG priming" effect in controlled ovarian stimulation through a long protocol Beretsos, Panagiotis Partsinevelos, George A Arabatzi, Eleni Drakakis, Peter Mavrogianni, Depy Anagnostou, Elli Stefanidis, Kostas Antsaklis, Aris Loutradis, Dimitris Reprod Biol Endocrinol Research BACKGROUND: Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa), a short-term pre-treatment with recombinant LH (rLH), prior to recombinant FSH (rFSH) administration, increases the number of small antral follicle prior to FSH stimulation and the yield of normally fertilized embryos. However, no data exist in the literature regarding the potential beneficial effect of "hCG priming" in controlled ovarian hyperstimulation (COH) through a long GnRH-a protocol, which binds the same receptor (LH/hCGR), though it is a much more potent compared to LH. The primary aims of this study were to assess the effect of short-term pre-rFSH administration of hCG in women entering an ICSI treatment cycle on follicular development, quality of oocytes and early embryo development. The secondary endpoints were to record the effects on endometrial quality and pregnancy rate. METHODS: Patients with a history of at least one previous unsuccessful ICSI cycle were randomly assigned into two groups to receive treatment with either a long protocol with rFSH (control group) or a long protocol with rFSH and pre-treatment with hCG (hCG group). In particular, in the latter group, a fixed 7 days course of 200 IU/day hCG was administered as soon as pituitary desensitization was confirmed. RESULTS: The mean number of oocytes retrieved was not significantly different between the two treatment groups, although the percentage of mature oocytes tended to be higher but not significantly different in hCG-treated patients. The percentage of patients with more than one grade 3 embryos was higher in the pre-treatment group, which also showed a higher pregnancy rate. CONCLUSION: All the above clinical observations, in conjunction with previous data, suggest a point towards a beneficial "hCG priming" effect in controlled ovarian hyperstimulation through a long GnRH-a down-regulation protocol, particularly in patients with previous ART failures. BioMed Central 2009-08-31 /pmc/articles/PMC2744681/ /pubmed/19719843 http://dx.doi.org/10.1186/1477-7827-7-91 Text en Copyright © 2009 Beretsos et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Beretsos, Panagiotis
Partsinevelos, George A
Arabatzi, Eleni
Drakakis, Peter
Mavrogianni, Depy
Anagnostou, Elli
Stefanidis, Kostas
Antsaklis, Aris
Loutradis, Dimitris
"hCG priming" effect in controlled ovarian stimulation through a long protocol
title "hCG priming" effect in controlled ovarian stimulation through a long protocol
title_full "hCG priming" effect in controlled ovarian stimulation through a long protocol
title_fullStr "hCG priming" effect in controlled ovarian stimulation through a long protocol
title_full_unstemmed "hCG priming" effect in controlled ovarian stimulation through a long protocol
title_short "hCG priming" effect in controlled ovarian stimulation through a long protocol
title_sort "hcg priming" effect in controlled ovarian stimulation through a long protocol
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744681/
https://www.ncbi.nlm.nih.gov/pubmed/19719843
http://dx.doi.org/10.1186/1477-7827-7-91
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