Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Mutations in PINK1 and parkin cause autosomal recessive parkinsonism, a neurodegenerative disorder characterized by the loss of dopaminergic neurons. To highlight potential therapeutic pathways we have identified factors that genetically interact with parkin/PINK1. Here we report that overexpression...

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Detalles Bibliográficos
Autores principales: Tain, Luke S, Mortiboys, Heather, Tao, Ran N, Ziviani, Elena, Bandmann, Oliver, Whitworth, Alexander J
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745154/
https://www.ncbi.nlm.nih.gov/pubmed/19684592
http://dx.doi.org/10.1038/nn.2372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745154/
https://www.ncbi.nlm.nih.gov/pubmed/19684592
http://dx.doi.org/10.1038/nn.2372

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