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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
Mutations in PINK1 and parkin cause autosomal recessive parkinsonism, a neurodegenerative disorder characterized by the loss of dopaminergic neurons. To highlight potential therapeutic pathways we have identified factors that genetically interact with parkin/PINK1. Here we report that overexpression...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745154/ https://www.ncbi.nlm.nih.gov/pubmed/19684592 http://dx.doi.org/10.1038/nn.2372 |