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The Past and Future of Tuberculosis Research
Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, diabetes, and multidrug resistance—all of which contribute to susceptibility to TB—global control of t...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745564/ https://www.ncbi.nlm.nih.gov/pubmed/19855821 http://dx.doi.org/10.1371/journal.ppat.1000600 |
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author | Comas, Iñaki Gagneux, Sebastien |
author_facet | Comas, Iñaki Gagneux, Sebastien |
author_sort | Comas, Iñaki |
collection | PubMed |
description | Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, diabetes, and multidrug resistance—all of which contribute to susceptibility to TB—global control of the disease will remain a formidable challenge for years to come. New high-throughput genomics technologies are already contributing to studies of TB's epidemiology, comparative genomics, evolution, and host–pathogen interaction. We argue here, however, that new multidisciplinary approaches—especially the integration of epidemiology with systems biology in what we call “systems epidemiology”—will be required to eliminate TB. |
format | Text |
id | pubmed-2745564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-27455642009-10-26 The Past and Future of Tuberculosis Research Comas, Iñaki Gagneux, Sebastien PLoS Pathog Review Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, diabetes, and multidrug resistance—all of which contribute to susceptibility to TB—global control of the disease will remain a formidable challenge for years to come. New high-throughput genomics technologies are already contributing to studies of TB's epidemiology, comparative genomics, evolution, and host–pathogen interaction. We argue here, however, that new multidisciplinary approaches—especially the integration of epidemiology with systems biology in what we call “systems epidemiology”—will be required to eliminate TB. Public Library of Science 2009-10-26 /pmc/articles/PMC2745564/ /pubmed/19855821 http://dx.doi.org/10.1371/journal.ppat.1000600 Text en Comas, Gagneux. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Review Comas, Iñaki Gagneux, Sebastien The Past and Future of Tuberculosis Research |
title | The Past and Future of Tuberculosis Research |
title_full | The Past and Future of Tuberculosis Research |
title_fullStr | The Past and Future of Tuberculosis Research |
title_full_unstemmed | The Past and Future of Tuberculosis Research |
title_short | The Past and Future of Tuberculosis Research |
title_sort | past and future of tuberculosis research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745564/ https://www.ncbi.nlm.nih.gov/pubmed/19855821 http://dx.doi.org/10.1371/journal.ppat.1000600 |
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