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Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies

INTRODUCTION: The aim of this study was to examine IL-17A in patients, following anti-TNF-α therapy and the effect of IL-17A on matrix turnover and cartilage degradation. METHODS: IL-17A expression was examined by ELISA and immunohistology in the rheumatoid arthritis (RA) joints. RA whole synovial t...

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Detalles Bibliográficos
Autores principales:	Moran, Ellen M, Mullan, Ronan, McCormick, Jennifer, Connolly, Mary, Sullivan, Owen, FitzGerald, Oliver, Bresnihan, Barry, Veale, Douglas J, Fearon, Ursula
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745795/ https://www.ncbi.nlm.nih.gov/pubmed/19627579 http://dx.doi.org/10.1186/ar2772

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