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Hyperprolactinaemia with amisulpride
Amisulpride, a substituted benzamide derivative, is a second-generation antipsychotic that preferentially binds to D2/D3 receptors in limbic rather than striatal structures. High dosage preferentially antagonizes postsynaptic receptors, resulting in reduced dopamine transmission; and low dosage bloc...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745860/ https://www.ncbi.nlm.nih.gov/pubmed/19771309 http://dx.doi.org/10.4103/0019-5545.39761 |
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author | Raj, Rajnish Sidhu, Balwant Singh |
author_facet | Raj, Rajnish Sidhu, Balwant Singh |
author_sort | Raj, Rajnish |
collection | PubMed |
description | Amisulpride, a substituted benzamide derivative, is a second-generation antipsychotic that preferentially binds to D2/D3 receptors in limbic rather than striatal structures. High dosage preferentially antagonizes postsynaptic receptors, resulting in reduced dopamine transmission; and low dosage blocks presynaptic receptors, resulting in enhanced transmission. Hyperprolactinaemia may occur in patients receiving amisulpride at low dose of 50 mg/day and results in galactorrhoea, amenorrhea and sexual dysfunction. The symptom ameliorates on withdrawing the drug, switching to non-prolactin-elevating drugs, and timely management with dopamine agonist. |
format | Text |
id | pubmed-2745860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-27458602009-09-21 Hyperprolactinaemia with amisulpride Raj, Rajnish Sidhu, Balwant Singh Indian J Psychiatry Case Report Amisulpride, a substituted benzamide derivative, is a second-generation antipsychotic that preferentially binds to D2/D3 receptors in limbic rather than striatal structures. High dosage preferentially antagonizes postsynaptic receptors, resulting in reduced dopamine transmission; and low dosage blocks presynaptic receptors, resulting in enhanced transmission. Hyperprolactinaemia may occur in patients receiving amisulpride at low dose of 50 mg/day and results in galactorrhoea, amenorrhea and sexual dysfunction. The symptom ameliorates on withdrawing the drug, switching to non-prolactin-elevating drugs, and timely management with dopamine agonist. Medknow Publications 2008 /pmc/articles/PMC2745860/ /pubmed/19771309 http://dx.doi.org/10.4103/0019-5545.39761 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Raj, Rajnish Sidhu, Balwant Singh Hyperprolactinaemia with amisulpride |
title | Hyperprolactinaemia with amisulpride |
title_full | Hyperprolactinaemia with amisulpride |
title_fullStr | Hyperprolactinaemia with amisulpride |
title_full_unstemmed | Hyperprolactinaemia with amisulpride |
title_short | Hyperprolactinaemia with amisulpride |
title_sort | hyperprolactinaemia with amisulpride |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745860/ https://www.ncbi.nlm.nih.gov/pubmed/19771309 http://dx.doi.org/10.4103/0019-5545.39761 |
work_keys_str_mv | AT rajrajnish hyperprolactinaemiawithamisulpride AT sidhubalwantsingh hyperprolactinaemiawithamisulpride |