Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants

BACKGROUND: Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP70 in various animal cell types. The aim of our study was to investigate whethe...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Szczepek, Agnieszka J, Haupt, Heidemarie, Mazurek, Birgit
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746196/
https://www.ncbi.nlm.nih.gov/pubmed/19723345
http://dx.doi.org/10.1186/1423-0127-16-79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746196/
https://www.ncbi.nlm.nih.gov/pubmed/19723345
http://dx.doi.org/10.1186/1423-0127-16-79

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