ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus

Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing a...

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Detalles Bibliográficos
Autores principales: Ries, S, Korn, W M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746528/
https://www.ncbi.nlm.nih.gov/pubmed/11857003
http://dx.doi.org/10.1038/sj.bjc.6600006
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author Ries, S
Korn, W M
author_facet Ries, S
Korn, W M
author_sort Ries, S
collection PubMed
description Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing and amplification of their oncolytic potential within the tumour mass. In this review, we describe the development of ONYX-015, one of the first and most advanced replication-competent viruses for cancer therapy. We discuss the molecular biology of this therapeutic approach and the interesting results obtained with this virus in clinical trials. British Journal of Cancer (2002) 86, 5–11. DOI: 10.1038/sj/bjc/6600006 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-27465282009-09-18 ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus Ries, S Korn, W M Br J Cancer Mini Review Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing and amplification of their oncolytic potential within the tumour mass. In this review, we describe the development of ONYX-015, one of the first and most advanced replication-competent viruses for cancer therapy. We discuss the molecular biology of this therapeutic approach and the interesting results obtained with this virus in clinical trials. British Journal of Cancer (2002) 86, 5–11. DOI: 10.1038/sj/bjc/6600006 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-01-07 /pmc/articles/PMC2746528/ /pubmed/11857003 http://dx.doi.org/10.1038/sj.bjc.6600006 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Mini Review
Ries, S
Korn, W M
ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title_full ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title_fullStr ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title_full_unstemmed ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title_short ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
title_sort onyx-015: mechanisms of action and clinical potential of a replication-selective adenovirus
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746528/
https://www.ncbi.nlm.nih.gov/pubmed/11857003
http://dx.doi.org/10.1038/sj.bjc.6600006
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AT kornwm onyx015mechanismsofactionandclinicalpotentialofareplicationselectiveadenovirus

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