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Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status
Neuroblastoma and its benign differentiated counterpart, ganglioneuroma, are paediatric neuroblastic tumours arising in the sympathetic nervous system. Their broad spectrum of clinical virulence is mainly related to heterogeneous biologic background and tumour differentiation. Neuroblastic tumours s...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746536/ https://www.ncbi.nlm.nih.gov/pubmed/11857022 http://dx.doi.org/10.1038/sj.bjc.6600019 |
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author | Perel, Y Amrein, L Dobremez, E Rivel, J Daniel, J Y Landry, M |
author_facet | Perel, Y Amrein, L Dobremez, E Rivel, J Daniel, J Y Landry, M |
author_sort | Perel, Y |
collection | PubMed |
description | Neuroblastoma and its benign differentiated counterpart, ganglioneuroma, are paediatric neuroblastic tumours arising in the sympathetic nervous system. Their broad spectrum of clinical virulence is mainly related to heterogeneous biologic background and tumour differentiation. Neuroblastic tumours synthesize various neuropeptides acting as neuromodulators. Previous studies suggested that galanin plays a role in sympathetic tissue where it could be involved in differentiation and development. We investigated the expression and distribution of galanin and its three known receptors (Gal-R1, Gal-R2, Gal-R3) in 19 samples of neuroblastic tumours tissue by immunohistochemistry, in situ hybridization and fluorescent-ligand binding. This study provides clear evidence for galanin and galanin receptor expression in human neuroblastic tumours. The messengers coding for galanin, Gal-R1 and -R3 were highly expressed in neuroblastoma and their amount dramatically decreased in ganglioneuroma. In contrast, Gal-R2 levels remained unchanged. Double labelling studies showed that galanin was mainly co-expressed with its receptors whatever the differentiation stage. In neuroblastic tumours, galanin might promote cell-survival or counteract neuronal differentiation through the different signalling pathways mediated by galanin receptors. Finally, our results suggest that galanin influences neuroblastoma growth and development as an autocrine/paracrine modulator. These findings suggest potential critical implications for galanin in neuroblastic tumours development. British Journal of Cancer (2002) 86, 117–122. DOI: 10.1038/sj/bjc/6600019 www.bjcancer.com © 2002 The Cancer Research Campaign |
format | Text |
id | pubmed-2746536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-27465362009-09-18 Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status Perel, Y Amrein, L Dobremez, E Rivel, J Daniel, J Y Landry, M Br J Cancer Molecular and Cellular Pathology Neuroblastoma and its benign differentiated counterpart, ganglioneuroma, are paediatric neuroblastic tumours arising in the sympathetic nervous system. Their broad spectrum of clinical virulence is mainly related to heterogeneous biologic background and tumour differentiation. Neuroblastic tumours synthesize various neuropeptides acting as neuromodulators. Previous studies suggested that galanin plays a role in sympathetic tissue where it could be involved in differentiation and development. We investigated the expression and distribution of galanin and its three known receptors (Gal-R1, Gal-R2, Gal-R3) in 19 samples of neuroblastic tumours tissue by immunohistochemistry, in situ hybridization and fluorescent-ligand binding. This study provides clear evidence for galanin and galanin receptor expression in human neuroblastic tumours. The messengers coding for galanin, Gal-R1 and -R3 were highly expressed in neuroblastoma and their amount dramatically decreased in ganglioneuroma. In contrast, Gal-R2 levels remained unchanged. Double labelling studies showed that galanin was mainly co-expressed with its receptors whatever the differentiation stage. In neuroblastic tumours, galanin might promote cell-survival or counteract neuronal differentiation through the different signalling pathways mediated by galanin receptors. Finally, our results suggest that galanin influences neuroblastoma growth and development as an autocrine/paracrine modulator. These findings suggest potential critical implications for galanin in neuroblastic tumours development. British Journal of Cancer (2002) 86, 117–122. DOI: 10.1038/sj/bjc/6600019 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-01-07 /pmc/articles/PMC2746536/ /pubmed/11857022 http://dx.doi.org/10.1038/sj.bjc.6600019 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular and Cellular Pathology Perel, Y Amrein, L Dobremez, E Rivel, J Daniel, J Y Landry, M Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title | Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title_full | Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title_fullStr | Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title_full_unstemmed | Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title_short | Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
title_sort | galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status |
topic | Molecular and Cellular Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746536/ https://www.ncbi.nlm.nih.gov/pubmed/11857022 http://dx.doi.org/10.1038/sj.bjc.6600019 |
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