The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy

Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potentia...

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Detalles Bibliográficos
Autores principales: Lu, Xinjie, Lu, Dong, Scully, Mike, Kakkar, Vijay
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746574/
https://www.ncbi.nlm.nih.gov/pubmed/19787098
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author Lu, Xinjie
Lu, Dong
Scully, Mike
Kakkar, Vijay
author_facet Lu, Xinjie
Lu, Dong
Scully, Mike
Kakkar, Vijay
author_sort Lu, Xinjie
collection PubMed
description Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.
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spelling pubmed-27465742009-09-28 The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy Lu, Xinjie Lu, Dong Scully, Mike Kakkar, Vijay Perspect Medicin Chem Perspective Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target. Libertas Academica 2008-04-10 /pmc/articles/PMC2746574/ /pubmed/19787098 Text en © 2009 The authors. http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Perspective
Lu, Xinjie
Lu, Dong
Scully, Mike
Kakkar, Vijay
The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title_full The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title_fullStr The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title_full_unstemmed The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title_short The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
title_sort role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746574/
https://www.ncbi.nlm.nih.gov/pubmed/19787098
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