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Effects of FK506 on Ca(2+) Release Channels (Review)

Tacrolimus (FK506), which was isolated from the fermentation broth of Streptomyces tsukubaensis No. 9993, has an immunosuppressive effect. In T-lymphocytes, FK506 binds to the intracellular receptor, a 12-kDa FK506-binding protein (FKBP12). The FK506-FKBP12 complex binds to the phosphatase calcineur...

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Detalles Bibliográficos
Autor principal:	Ozawa, Terutaka
Formato:	Texto
Lenguaje:	English
Publicado:	Libertas Academica 2008
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746578/ https://www.ncbi.nlm.nih.gov/pubmed/19787097

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