Generation of dendritic cell-based vaccines for cancer therapy

Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we disc...

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Detalles Bibliográficos
Autores principales: Reinhard, G, Märten, A, Kiske, S M, Feil, F, Bieber, T, Schmidt-Wolf, I G H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746586/
https://www.ncbi.nlm.nih.gov/pubmed/12085199
http://dx.doi.org/10.1038/sj.bjc.6600316
Descripción
Sumario:Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response. British Journal of Cancer (2002) 86, 1529–1533. DOI: 10.1038/sj/bjc/6600316 www.bjcancer.com © 2002 Cancer Research UK

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