Single molecule conformational analysis of DNA G-quadruplexes

Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter...

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Detalles Bibliográficos
Autores principales: Shirude, Pravin S., Balasubramanian, Shankar
Formato: Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746965/
https://www.ncbi.nlm.nih.gov/pubmed/18295608
http://dx.doi.org/10.1016/j.biochi.2008.01.015
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author Shirude, Pravin S.
Balasubramanian, Shankar
author_facet Shirude, Pravin S.
Balasubramanian, Shankar
author_sort Shirude, Pravin S.
collection PubMed
description Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter of a proto-oncogene. The findings are discussed with respect to the proposed biological function(s) of such motifs in living cells.
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spelling pubmed-27469652009-09-21 Single molecule conformational analysis of DNA G-quadruplexes Shirude, Pravin S. Balasubramanian, Shankar Biochimie Review Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter of a proto-oncogene. The findings are discussed with respect to the proposed biological function(s) of such motifs in living cells. Editions Scientifiques Elsevier 2008-08 /pmc/articles/PMC2746965/ /pubmed/18295608 http://dx.doi.org/10.1016/j.biochi.2008.01.015 Text en © 2008 Elsevier Masson SAS. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Shirude, Pravin S.
Balasubramanian, Shankar
Single molecule conformational analysis of DNA G-quadruplexes
title Single molecule conformational analysis of DNA G-quadruplexes
title_full Single molecule conformational analysis of DNA G-quadruplexes
title_fullStr Single molecule conformational analysis of DNA G-quadruplexes
title_full_unstemmed Single molecule conformational analysis of DNA G-quadruplexes
title_short Single molecule conformational analysis of DNA G-quadruplexes
title_sort single molecule conformational analysis of dna g-quadruplexes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746965/
https://www.ncbi.nlm.nih.gov/pubmed/18295608
http://dx.doi.org/10.1016/j.biochi.2008.01.015
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