Cell Cycle Re-Entry and Mitochondrial Defects in Myc-Mediated Hypertrophic Cardiomyopathy and Heart Failure

While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a “fetal re-expression” pattern, the functional role of Myc in mechanisms of cardiomyopathy remains unclear. To address this, we developed a bitransgenic mouse that inducibly...

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Detalles Bibliográficos
Autores principales: Lee, Hyoung-gon, Chen, Qun, Wolfram, Julie A., Richardson, Sandy L., Liner, Anna, Siedlak, Sandra L., Zhu, Xiongwei, Ziats, Nicholas P., Fujioka, Hisashi, Felsher, Dean W., Castellani, Rudy J., Valencik, Maria L., McDonald, John A., Hoit, Brian D., Lesnefsky, Edward J., Smith, Mark A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747003/
https://www.ncbi.nlm.nih.gov/pubmed/19779629
http://dx.doi.org/10.1371/journal.pone.0007172

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