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Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis lymphatic valve leaflet formation is initiated by upregulation of integrin-α9 expression and deposition of its ligand, fibronectin-EIIIA (F...

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Detalles Bibliográficos
Autores principales:	Bazigou, Eleni, Xie, Sherry, Chen, Chun, Weston, Anne, Miura, Naoyuki, Sorokin, Lydia, Adams, Ralf, Muro, Andrés F., Sheppard, Dean, Makinen, Taija
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747264/ https://www.ncbi.nlm.nih.gov/pubmed/19686679 http://dx.doi.org/10.1016/j.devcel.2009.06.017

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