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Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review

Pain is a frequent and important symptom in cancer patients. Among the available strong opioids, transdermal buprenorphine has been licensed in Europe since 2002, and results from a few clinical studies suggest that it may be a good alternative to the other oral or transdermal opioids. To assess the...

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Detalles Bibliográficos
Autores principales: Deandrea, S, Corli, O, Moschetti, I, Apolone, G
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747389/
https://www.ncbi.nlm.nih.gov/pubmed/19774212
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author Deandrea, S
Corli, O
Moschetti, I
Apolone, G
author_facet Deandrea, S
Corli, O
Moschetti, I
Apolone, G
author_sort Deandrea, S
collection PubMed
description Pain is a frequent and important symptom in cancer patients. Among the available strong opioids, transdermal buprenorphine has been licensed in Europe since 2002, and results from a few clinical studies suggest that it may be a good alternative to the other oral or transdermal opioids. To assess the best available evidence on its efficacy and safety, we carried out a systematic literature review with the aim of pooling relevant studies. We identified 19 eligible papers describing 12 clinical studies (6 randomized controlled trials and 6 observational prospective studies), including a total of about 5000 cancer patients. Given the poor quality of reports and the heterogeneity of methods and outcomes, pooling was not feasible as the type of data was not appropriate for combining the results statistically. A meta-analysis based on individual data is ongoing in the context of the Cochrane Collaboration. In conclusion, although the narrative appraisal of each study suggests a positive risk benefit profile, well designed and statistically powered controlled clinical trials are needed to confirm this preliminary evidence.
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spelling pubmed-27473892009-09-22 Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review Deandrea, S Corli, O Moschetti, I Apolone, G Ther Clin Risk Manag Review Pain is a frequent and important symptom in cancer patients. Among the available strong opioids, transdermal buprenorphine has been licensed in Europe since 2002, and results from a few clinical studies suggest that it may be a good alternative to the other oral or transdermal opioids. To assess the best available evidence on its efficacy and safety, we carried out a systematic literature review with the aim of pooling relevant studies. We identified 19 eligible papers describing 12 clinical studies (6 randomized controlled trials and 6 observational prospective studies), including a total of about 5000 cancer patients. Given the poor quality of reports and the heterogeneity of methods and outcomes, pooling was not feasible as the type of data was not appropriate for combining the results statistically. A meta-analysis based on individual data is ongoing in the context of the Cochrane Collaboration. In conclusion, although the narrative appraisal of each study suggests a positive risk benefit profile, well designed and statistically powered controlled clinical trials are needed to confirm this preliminary evidence. Dove Medical Press 2009 2009-09-15 /pmc/articles/PMC2747389/ /pubmed/19774212 Text en © 2009 Deandrea et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Deandrea, S
Corli, O
Moschetti, I
Apolone, G
Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title_full Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title_fullStr Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title_full_unstemmed Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title_short Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
title_sort managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747389/
https://www.ncbi.nlm.nih.gov/pubmed/19774212
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