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Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids

Temozolomide is an alkylating cytostatic drug that finds increasing application in the treatment of melanoma, anaplastic astrocytoma and glioblastoma multiforme. The compound is a prodrug that decomposes spontaneously, independent of an enzymatic activation step. DNA methylation induces futile misma...

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Detalles Bibliográficos
Autores principales:	Günther, W, Pawlak, E, Damasceno, R, Arnold, H, Terzis, A J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747547/ https://www.ncbi.nlm.nih.gov/pubmed/12569392 http://dx.doi.org/10.1038/sj.bjc.6600711

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