Cargando…

A role for BRCA1 in sporadic breast cancer

To test the hypothesis that altered expression of BRCA1 protein may play an important role in sporadic breast cancer development, 50 randomly selected primary breast cancers (frozen sections, 5 years' median follow-up) were immunolabelled with two monoclonal BRCA1 antibodies (MS110 and MS13). M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fraser, J A, Reeves, J R, Stanton, P D, Black, D M, Going, J J, Cooke, T G, Bartlett, J M S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747570/ https://www.ncbi.nlm.nih.gov/pubmed/12698194 http://dx.doi.org/10.1038/sj.bjc.6600863

Ejemplares similares

Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype
por: Mitra, A, et al.
Publicado: (2008)

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
por: Osorio, A, et al.
Publicado: (2009)

Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation
por: Metcalfe, K A, et al.
Publicado: (2009)

The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
por: Iqbal, J, et al.
Publicado: (2012)

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Sinilnikova, O M, et al.
Publicado: (2009)

An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers
por: Osorio, A, et al.
Publicado: (2008)

BRCA2 gene mutations in families with aggregations of breast and stomach cancers
por: Jakubowska, A, et al.
Publicado: (2002)

Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study
por: Phelan, C M, et al.
Publicado: (2014)

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
por: Osorio, A, et al.
Publicado: (2011)

BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families
por: Claes, K, et al.
Publicado: (2004)

DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas
por: Kamieniak, M M, et al.
Publicado: (2013)

Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers
por: Lips, E H, et al.
Publicado: (2013)

Optimal selection for BRCA1 and BRCA2 mutation testing using a combination of ‘easy to apply’ probability models
por: Bodmer, D, et al.
Publicado: (2006)

A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers
por: Kadouri, L, et al.
Publicado: (2004)

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma
por: Astuti, D, et al.
Publicado: (2004)

MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours
por: Tanic, M, et al.
Publicado: (2013)

Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers
por: Kadouri, L, et al.
Publicado: (2008)

BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years
por: Robertson, L, et al.
Publicado: (2012)

Germline BRCA1 mutations increase prostate cancer risk
por: Leongamornlert, D, et al.
Publicado: (2012)

CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status
por: Gudmundsdottir, K, et al.
Publicado: (2003)

TGFBR1(*)6A and Int7G24A variants of transforming growth factor-β receptor 1 in Swedish familial and sporadic breast cancer
por: Song, B, et al.
Publicado: (2007)

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
por: Jakubowska, A, et al.
Publicado: (2012)

Uptake of risk-reducing salpingo-oophorectomy in women carrying a BRCA1 or BRCA2 mutation: evidence for lower uptake in women affected by breast cancer and older women
por: Sidon, L, et al.
Publicado: (2012)

Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions
por: Moon, D H, et al.
Publicado: (2013)

The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
por: Akbari, M R, et al.
Publicado: (2014)

Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade
por: Ding, S L, et al.
Publicado: (2004)

BRCA1 and BRCA2 mutations in Scotland and Northern Ireland
Publicado: (2003)

The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study
por: Iqbal, Javaid, et al.
Publicado: (2016)

Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
por: Edwards, S M, et al.
Publicado: (2010)

Rapid progression of prostate cancer in men with a BRCA2 mutation
por: Narod, S A, et al.
Publicado: (2008)

Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays
por: Bièche, I, et al.
Publicado: (2002)

Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer
por: Agalliu, I, et al.
Publicado: (2007)

Gene expression profiling integrated into network modelling reveals heterogeneity in the mechanisms of BRCA1 tumorigenesis
por: Fernández-Ramires, R, et al.
Publicado: (2009)

Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers
por: Kote-Jarai, Z, et al.
Publicado: (2006)

Low-level constitutional mosaicism of a de novoBRCA1 gene mutation
por: Friedman, E, et al.
Publicado: (2015)

Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
por: Detours, V, et al.
Publicado: (2007)

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
por: Barker, K T, et al.
Publicado: (2002)

Identification of DBC1 as a transcriptional repressor for BRCA1
por: Hiraike, H, et al.
Publicado: (2010)

Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia
por: Scardocci, A, et al.
Publicado: (2006)

Male breast cancer, age and sex chromosome aneuploidy
por: Jacobs, P A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kdp04sjeno34vkkv9m3qn5idfi