Methylation pattern of CDH13 gene in digestive tract cancers

Recently, the loss of CDH13 (T-cadherin, H-cadherin) gene expression accompanied by CDH13 promoter methylation was identified in colon cancers. We examined CDH13 methylation in oesophageal and gastric carcinomas. Five of 37 oesophageal cancers (14%) and 23 of 66 gastric cancers (35%) demonstrated ab...

Descripción completa

Detalles Bibliográficos
Autores principales: Hibi, K, Kodera, Y, Ito, K, Akiyama, S, Nakao, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747686/
https://www.ncbi.nlm.nih.gov/pubmed/15292927
http://dx.doi.org/10.1038/sj.bjc.6602095
_version_ 1782172114842812416
author Hibi, K
Kodera, Y
Ito, K
Akiyama, S
Nakao, A
author_facet Hibi, K
Kodera, Y
Ito, K
Akiyama, S
Nakao, A
author_sort Hibi, K
collection PubMed
description Recently, the loss of CDH13 (T-cadherin, H-cadherin) gene expression accompanied by CDH13 promoter methylation was identified in colon cancers. We examined CDH13 methylation in oesophageal and gastric carcinomas. Five of 37 oesophageal cancers (14%) and 23 of 66 gastric cancers (35%) demonstrated abnormal methylation of the CDH13 promoter. Abnormal methylation was frequently found in gastric cancers of patients at all clinical stages just as in E-cadherin, another of the cadherin family, suggesting that these cancers could be methylated at an early stage. These results suggested that CDH13 might play a variety of roles depending on the tissue type.
format Text
id pubmed-2747686
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-27476862009-09-21 Methylation pattern of CDH13 gene in digestive tract cancers Hibi, K Kodera, Y Ito, K Akiyama, S Nakao, A Br J Cancer Genetics and Genomics Recently, the loss of CDH13 (T-cadherin, H-cadherin) gene expression accompanied by CDH13 promoter methylation was identified in colon cancers. We examined CDH13 methylation in oesophageal and gastric carcinomas. Five of 37 oesophageal cancers (14%) and 23 of 66 gastric cancers (35%) demonstrated abnormal methylation of the CDH13 promoter. Abnormal methylation was frequently found in gastric cancers of patients at all clinical stages just as in E-cadherin, another of the cadherin family, suggesting that these cancers could be methylated at an early stage. These results suggested that CDH13 might play a variety of roles depending on the tissue type. Nature Publishing Group 2004-09-13 2004-08-03 /pmc/articles/PMC2747686/ /pubmed/15292927 http://dx.doi.org/10.1038/sj.bjc.6602095 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Hibi, K
Kodera, Y
Ito, K
Akiyama, S
Nakao, A
Methylation pattern of CDH13 gene in digestive tract cancers
title Methylation pattern of CDH13 gene in digestive tract cancers
title_full Methylation pattern of CDH13 gene in digestive tract cancers
title_fullStr Methylation pattern of CDH13 gene in digestive tract cancers
title_full_unstemmed Methylation pattern of CDH13 gene in digestive tract cancers
title_short Methylation pattern of CDH13 gene in digestive tract cancers
title_sort methylation pattern of cdh13 gene in digestive tract cancers
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747686/
https://www.ncbi.nlm.nih.gov/pubmed/15292927
http://dx.doi.org/10.1038/sj.bjc.6602095
work_keys_str_mv AT hibik methylationpatternofcdh13geneindigestivetractcancers
AT koderay methylationpatternofcdh13geneindigestivetractcancers
AT itok methylationpatternofcdh13geneindigestivetractcancers
AT akiyamas methylationpatternofcdh13geneindigestivetractcancers
AT nakaoa methylationpatternofcdh13geneindigestivetractcancers

Ejemplares similares