Cargando…

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion

The effects of indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019, or FFC14A), the second ruthenium compound that entered clinical trials, in an in vitro model of tumour invasion and metastasis show that the antitumour effects of this compound might include also the modulation of c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bergamo, A., Masi, A., Jakupec, M. A., Keppler, B. K., Sava, G.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748298/ https://www.ncbi.nlm.nih.gov/pubmed/19789639 http://dx.doi.org/10.1155/2009/681270

Ejemplares similares

DMSO reduces the cytotoxicity of anticancer ruthenium complex KP1019 in yeast
por: Davis, Jonathan, et al.
Publicado: (2021)

En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity of trans-[Os(IV)Cl(4)(Hazole)(2)]
por: Büchel, Gabriel E., et al.
Publicado: (2011)

X-ray Absorption Near Edge Structure Spectroscopy to Resolve the in Vivo Chemistry of the Redox-Active Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019)
por: Hummer, Alfred A., et al.
Publicado: (2013)

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry
por: Alessio, Enzo, et al.
Publicado: (2019)

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
por: Bijelic, Aleksandar, et al.
Publicado: (2016)

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
por: Novak, Maria S., et al.
Publicado: (2016)

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo()
por: Heffeter, Petra, et al.
Publicado: (2013)

Pharmacological Activities of Ruthenium Complexes Related to Their NO Scavenging Properties
por: Castellarin, Anna, et al.
Publicado: (2016)

DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae
por: Bierle, Lindsey A., et al.
Publicado: (2015)

Correction: DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae
Publicado: (2015)

A systematic assessment of chemical, genetic, and epigenetic factors influencing the activity of anticancer drug KP1019 (FFC14A)
por: Golla, Upendarrao, et al.
Publicado: (2017)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
por: Kater, Lisa, et al.
Publicado: (2021)

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
por: Hanif, Muhammad, et al.
Publicado: (2013)

Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma
por: Zorzet, Sonia, et al.
Publicado: (2001)

Physicochemical Studies and Anticancer Potency of Ruthenium η(6)-p-Cymene Complexes Containing Antibacterial Quinolones
por: Kljun, Jakob, et al.
Publicado: (2011)

Molecular mode of action of NKP-1339 – a clinically investigated ruthenium-based drug – involves ER- and ROS-related effects in colon carcinoma cell lines
por: Flocke, Lea S., et al.
Publicado: (2016)

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
por: Filak, Lukas K., et al.
Publicado: (2010)

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group
por: Mokesch, Stephan, et al.
Publicado: (2019)

Binding of Antitumor Ruthenium(III) Complexes to Plasma Proteins
por: Messori, L., et al.
Publicado: (2000)

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
por: Filak, Lukas K., et al.
Publicado: (2013)

Water-Soluble Ruthenium(III)-Dimethyl Sulfoxide Complexes: Chemical Behaviour and Pharmaceutical Properties
por: Mestroni, G., et al.
Publicado: (1994)

The functional −1019C/G HTR1A polymorphism and mechanisms of fear
por: Straube, B, et al.
Publicado: (2014)

Striking Difference in Antiproliferative Activity of Ruthenium- and Osmium-Nitrosyl Complexes with Azole Heterocycles
por: Büchel, Gabriel E., et al.
Publicado: (2013)

PReS-FINAL-1019: Inflammatory monocytes induce resistance of effector t cells to suppression
por: Wehrens, EJ, et al.
Publicado: (2013)

Antiangiogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers
por: Morbidelli, L, et al.
Publicado: (2003)

Model independent calculation of Kp dispersion relations
por: López, C, et al.
Publicado: (1972)

Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d'Anglemont de Tassigny, Xavier, et al.
Publicado: (2017)

Ruthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c]quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity
por: Filak, Lukas K., et al.
Publicado: (2012)

Synthesis and in vitro Antitumor Potency of (Cyclohexane-1,2-Diamine)Platinum(II) Complexes with Aminotris(Methylenephosphonic Acid) as Bone-Seeking Ligand
por: Galanski, Markus, et al.
Publicado: (2005)

Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies
por: Cseh, Klaudia, et al.
Publicado: (2022)

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
por: Geisler, Heiko, et al.
Publicado: (2021)

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes
por: Dragutan, Ileana, et al.
Publicado: (2015)

Obituary – Dr. KP Srivastava
por: Pruthi, KK
Publicado: (2017)

Practice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia
por: Barbui, T, et al.
Publicado: (2015)

Asthma diagnosis and treatment – 1019. Churg Strauss Syndrome – missed diagnosis and consequences
por: Kamdar, Mahomed Cassim
Publicado: (2013)

1019. The Future is Embedded in the Present - Characterizing Pharmacist Interventions in an Infectious Diseases Clinic
por: Depcinski, Shawn, et al.
Publicado: (2022)

Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2018)

D-particles, Matrix Integrals and KP hierachy
por: Kazakov, Vladimir A., et al.
Publicado: (1998)

Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes
por: Varbanov, Hristo P., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nb3cfc9ulgromligh57m93osa8