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Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity
Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748688/ https://www.ncbi.nlm.nih.gov/pubmed/19777131 http://dx.doi.org/10.3762/bjoc.5.36 |
| _version_ | 1782172140629393408 |
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| author | Khunnawutmanotham, Nisachon Chimnoi, Nitirat Thitithanyanont, Arunee Saparpakorn, Patchreenart Choowongkomon, Kiattawee Pungpo, Pornpan Hannongbua, Supa Techasakul, Supanna |
| author_facet | Khunnawutmanotham, Nisachon Chimnoi, Nitirat Thitithanyanont, Arunee Saparpakorn, Patchreenart Choowongkomon, Kiattawee Pungpo, Pornpan Hannongbua, Supa Techasakul, Supanna |
| author_sort | Khunnawutmanotham, Nisachon |
| collection | PubMed |
| description | Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT. |
| format | Text |
| id | pubmed-2748688 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27486882009-09-23 Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity Khunnawutmanotham, Nisachon Chimnoi, Nitirat Thitithanyanont, Arunee Saparpakorn, Patchreenart Choowongkomon, Kiattawee Pungpo, Pornpan Hannongbua, Supa Techasakul, Supanna Beilstein J Org Chem Full Research Paper Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT. Beilstein-Institut 2009-07-22 /pmc/articles/PMC2748688/ /pubmed/19777131 http://dx.doi.org/10.3762/bjoc.5.36 Text en Copyright © 2009, Khunnawutmanotham et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Khunnawutmanotham, Nisachon Chimnoi, Nitirat Thitithanyanont, Arunee Saparpakorn, Patchreenart Choowongkomon, Kiattawee Pungpo, Pornpan Hannongbua, Supa Techasakul, Supanna Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title | Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title_full | Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title_fullStr | Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title_full_unstemmed | Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title_short | Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity |
| title_sort | dipyridodiazepinone derivatives; synthesis and anti hiv-1 activity |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748688/ https://www.ncbi.nlm.nih.gov/pubmed/19777131 http://dx.doi.org/10.3762/bjoc.5.36 |
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