Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)

Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures usin...

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Detalles Bibliográficos
Autores principales: Shore, Gjergji, Tsimerman, Michael, Organ, Michael G
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748690/
https://www.ncbi.nlm.nih.gov/pubmed/19777133
http://dx.doi.org/10.3762/bjoc.5.35
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author Shore, Gjergji
Tsimerman, Michael
Organ, Michael G
author_facet Shore, Gjergji
Tsimerman, Michael
Organ, Michael G
author_sort Shore, Gjergji
collection PubMed
description Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures using microwave irradiation. The transformation can be optimized rapidly, tolerates a wide number of functional groups, is highly regioselective, and proceeds in good to excellent conversion.
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spelling pubmed-27486902009-09-23 Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Shore, Gjergji Tsimerman, Michael Organ, Michael G Beilstein J Org Chem Full Research Paper Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures using microwave irradiation. The transformation can be optimized rapidly, tolerates a wide number of functional groups, is highly regioselective, and proceeds in good to excellent conversion. Beilstein-Institut 2009-07-21 /pmc/articles/PMC2748690/ /pubmed/19777133 http://dx.doi.org/10.3762/bjoc.5.35 Text en Copyright © 2009, Shore et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Shore, Gjergji
Tsimerman, Michael
Organ, Michael G
Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title_full Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title_fullStr Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title_full_unstemmed Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title_short Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)
title_sort gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (macos)
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748690/
https://www.ncbi.nlm.nih.gov/pubmed/19777133
http://dx.doi.org/10.3762/bjoc.5.35
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AT organmichaelg goldfilmcatalysedbenzannulationbymicrowaveassistedcontinuousfloworganicsynthesismacos

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