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Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker

Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor block...

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Detalles Bibliográficos
Autores principales: Blankestijn, P. J, Rupp, H
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748700/
https://www.ncbi.nlm.nih.gov/pubmed/18855637
http://dx.doi.org/10.2174/187152508785909500
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author Blankestijn, P. J
Rupp, H
author_facet Blankestijn, P. J
Rupp, H
author_sort Blankestijn, P. J
collection PubMed
description Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relatively new ARB which is chemically distinct (non-biphenyl, non-tetrazole) from all other ARBs (biphenyl tetrazoles). An analysis has been made on available experimental and clinical data on eprosartan which not only is an effective and well tolerated antihypertensive agent, but also lowers the activities of the renin-angiotensin system and sympathetic nervous system. Experimental and pharmacokinetic studies on eprosartan have shown differences with the other ARBs. The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity.
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spelling pubmed-27487002009-10-15 Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker Blankestijn, P. J Rupp, H Cardiovasc Hematol Agents Med Chem Article Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relatively new ARB which is chemically distinct (non-biphenyl, non-tetrazole) from all other ARBs (biphenyl tetrazoles). An analysis has been made on available experimental and clinical data on eprosartan which not only is an effective and well tolerated antihypertensive agent, but also lowers the activities of the renin-angiotensin system and sympathetic nervous system. Experimental and pharmacokinetic studies on eprosartan have shown differences with the other ARBs. The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity. Bentham Science Publishers Ltd. 2008-10 /pmc/articles/PMC2748700/ /pubmed/18855637 http://dx.doi.org/10.2174/187152508785909500 Text en © 2008 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Blankestijn, P. J
Rupp, H
Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title_full Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title_fullStr Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title_full_unstemmed Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title_short Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker
title_sort clinical profile of eprosartan: a different angiotensin ii receptor blocker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748700/
https://www.ncbi.nlm.nih.gov/pubmed/18855637
http://dx.doi.org/10.2174/187152508785909500
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