RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation

The fruitfly Drosophila melanogaster is well established as a model system in the study of human neurodegenerative diseases. Utilizing RNAi, we have carried out a high-throughput screen for modifiers of aggregate formation in Drosophila larval CNS-derived cells expressing mutant human Huntingtin exo...

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Detalles Bibliográficos
Autores principales: Doumanis, Joanna, Wada, Koji, Kino, Yoshihiro, Moore, Adrian W., Nukina, Nobuyuki
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748703/
https://www.ncbi.nlm.nih.gov/pubmed/19789644
http://dx.doi.org/10.1371/journal.pone.0007275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748703/
https://www.ncbi.nlm.nih.gov/pubmed/19789644
http://dx.doi.org/10.1371/journal.pone.0007275

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