Synthesis of phosphonate and phostone analogues of ribose-1-phosphates

The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the α- and β-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose series and a synthesis of the corresponding cyclic phostones of each α-ribose...

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Detalles Bibliográficos
Autores principales: Nasomjai, Pitak, O'Hagan, David, Slawin, Alexandra M Z
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748706/
https://www.ncbi.nlm.nih.gov/pubmed/19777136
http://dx.doi.org/10.3762/bjoc.5.37
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author Nasomjai, Pitak
O'Hagan, David
Slawin, Alexandra M Z
author_facet Nasomjai, Pitak
O'Hagan, David
Slawin, Alexandra M Z
author_sort Nasomjai, Pitak
collection PubMed
description The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the α- and β-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose series and a synthesis of the corresponding cyclic phostones of each α-ribose is also reported. These compounds have been prepared as tools to probe the details of fluorometabolism in S. cattleya.
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spelling pubmed-27487062009-09-23 Synthesis of phosphonate and phostone analogues of ribose-1-phosphates Nasomjai, Pitak O'Hagan, David Slawin, Alexandra M Z Beilstein J Org Chem Full Research Paper The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the α- and β-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose series and a synthesis of the corresponding cyclic phostones of each α-ribose is also reported. These compounds have been prepared as tools to probe the details of fluorometabolism in S. cattleya. Beilstein-Institut 2009-07-27 /pmc/articles/PMC2748706/ /pubmed/19777136 http://dx.doi.org/10.3762/bjoc.5.37 Text en Copyright © 2009, Nasomjai et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Nasomjai, Pitak
O'Hagan, David
Slawin, Alexandra M Z
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title_full Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title_fullStr Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title_full_unstemmed Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title_short Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
title_sort synthesis of phosphonate and phostone analogues of ribose-1-phosphates
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748706/
https://www.ncbi.nlm.nih.gov/pubmed/19777136
http://dx.doi.org/10.3762/bjoc.5.37
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