Splenectomy Normalizes Hematocrit in Murine Polycythemia Vera

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegaly and an increase in hematocrit. Splenectomy is sp...

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Detalles Bibliográficos
Autores principales: Mo, Jan-Rung, Mathur, Anjili, Angagaw, Minilik, Zhao, Shuxia, Wang, Yuxun, Gargano, Diana, DiBacco, Alessandra, Bachman, Eric S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749451/
https://www.ncbi.nlm.nih.gov/pubmed/19789710
http://dx.doi.org/10.1371/journal.pone.0007286

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