Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?

Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic β-catenin and the subsequent changes in the expression of T-cell factor (TC...

Descripción completa

Detalles Bibliográficos
Autores principales: Collu, Giovanna M, Meurette, Olivier, Brennan, Keith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750108/
https://www.ncbi.nlm.nih.gov/pubmed/19664193
http://dx.doi.org/10.1186/bcr2336
_version_ 1782172204700532736
author Collu, Giovanna M
Meurette, Olivier
Brennan, Keith
author_facet Collu, Giovanna M
Meurette, Olivier
Brennan, Keith
author_sort Collu, Giovanna M
collection PubMed
description Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic β-catenin and the subsequent changes in the expression of T-cell factor (TCF)-dependent genes. However, this is not necessarily the only mechanism, as Wnt proteins can signal through a number of different intracellular signalling pathways. The ongoing work from Nancy Hynes' laboratory continues to highlight this latter possibility.
format Text
id pubmed-2750108
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27501082009-09-25 Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin? Collu, Giovanna M Meurette, Olivier Brennan, Keith Breast Cancer Res Editorial Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic β-catenin and the subsequent changes in the expression of T-cell factor (TCF)-dependent genes. However, this is not necessarily the only mechanism, as Wnt proteins can signal through a number of different intracellular signalling pathways. The ongoing work from Nancy Hynes' laboratory continues to highlight this latter possibility. BioMed Central 2009 2009-07-30 /pmc/articles/PMC2750108/ /pubmed/19664193 http://dx.doi.org/10.1186/bcr2336 Text en Copyright © 2009 BioMed Central Ltd
spellingShingle Editorial
Collu, Giovanna M
Meurette, Olivier
Brennan, Keith
Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title_full Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title_fullStr Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title_full_unstemmed Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title_short Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?
title_sort is there more to wnt signalling in breast cancer than stabilisation of β-catenin?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750108/
https://www.ncbi.nlm.nih.gov/pubmed/19664193
http://dx.doi.org/10.1186/bcr2336
work_keys_str_mv AT collugiovannam istheremoretowntsignallinginbreastcancerthanstabilisationofbcatenin
AT meuretteolivier istheremoretowntsignallinginbreastcancerthanstabilisationofbcatenin
AT brennankeith istheremoretowntsignallinginbreastcancerthanstabilisationofbcatenin

Ejemplares similares