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Glucose absorption and gastric emptying in critical illness

INTRODUCTION: Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric...

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Autores principales: Chapman, Marianne J, Fraser, Robert JL, Matthews, Geoffrey, Russo, Antonietta, Bellon, Max, Besanko, Laura K, Jones, Karen L, Butler, Ross, Chatterton, Barry, Horowitz, Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750198/
https://www.ncbi.nlm.nih.gov/pubmed/19712450
http://dx.doi.org/10.1186/cc8021
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author Chapman, Marianne J
Fraser, Robert JL
Matthews, Geoffrey
Russo, Antonietta
Bellon, Max
Besanko, Laura K
Jones, Karen L
Butler, Ross
Chatterton, Barry
Horowitz, Michael
author_facet Chapman, Marianne J
Fraser, Robert JL
Matthews, Geoffrey
Russo, Antonietta
Bellon, Max
Besanko, Laura K
Jones, Karen L
Butler, Ross
Chatterton, Barry
Horowitz, Michael
author_sort Chapman, Marianne J
collection PubMed
description INTRODUCTION: Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and absorption has hitherto not been evaluated. The aim of this study was to quantify glucose absorption and the relationships between GE, glucose absorption and glycaemia in critically ill patients. METHODS: Studies were performed in nineteen mechanically-ventilated critically ill patients and compared to nineteen healthy subjects. Following 4 hours fasting, 100 ml of Ensure, 2 g 3-O-methyl glucose (3-OMG) and (99m)Tc sulphur colloid were infused into the stomach over 5 minutes. Glucose absorption (plasma 3-OMG), blood glucose levels and GE (scintigraphy) were measured over four hours. Data are mean ± SEM. A P-value < 0.05 was considered significant. RESULTS: Absorption of 3-OMG was markedly reduced in patients (AUC(240): 26.2 ± 18.4 vs. 66.6 ± 16.8; P < 0.001; peak: 0.17 ± 0.12 vs. 0.37 ± 0.098 mMol/l; P < 0.001; time to peak; 151 ± 84 vs. 89 ± 33 minutes; P = 0.007); and both the baseline (8.0 ± 2.1 vs. 5.6 ± 0.23 mMol/l; P < 0.001) and peak (10.0 ± 2.2 vs. 7.7 ± 0.2 mMol/l; P < 0.001) blood glucose levels were higher in patients; compared to healthy subjects. In patients; 3-OMG absorption was directly related to GE (AUC(240); r = -0.77 to -0.87; P < 0.001; peak concentrations; r = -0.75 to -0.81; P = 0.001; time to peak; r = 0.89-0.94; P < 0.001); but when GE was normal (percent retention(240 )< 10%; n = 9) absorption was still impaired. GE was inversely related to baseline blood glucose, such that elevated levels were associated with slower GE (ret 60, 180 and 240 minutes: r > 0.51; P < 0.05). CONCLUSIONS: In critically ill patients; (i) the rate and extent of glucose absorption are markedly reduced; (ii) GE is a major determinant of the rate of absorption, but does not fully account for the extent of impaired absorption; (iii) blood glucose concentration could be one of a number of factors affecting GE.
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spelling pubmed-27501982009-09-25 Glucose absorption and gastric emptying in critical illness Chapman, Marianne J Fraser, Robert JL Matthews, Geoffrey Russo, Antonietta Bellon, Max Besanko, Laura K Jones, Karen L Butler, Ross Chatterton, Barry Horowitz, Michael Crit Care Research INTRODUCTION: Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and absorption has hitherto not been evaluated. The aim of this study was to quantify glucose absorption and the relationships between GE, glucose absorption and glycaemia in critically ill patients. METHODS: Studies were performed in nineteen mechanically-ventilated critically ill patients and compared to nineteen healthy subjects. Following 4 hours fasting, 100 ml of Ensure, 2 g 3-O-methyl glucose (3-OMG) and (99m)Tc sulphur colloid were infused into the stomach over 5 minutes. Glucose absorption (plasma 3-OMG), blood glucose levels and GE (scintigraphy) were measured over four hours. Data are mean ± SEM. A P-value < 0.05 was considered significant. RESULTS: Absorption of 3-OMG was markedly reduced in patients (AUC(240): 26.2 ± 18.4 vs. 66.6 ± 16.8; P < 0.001; peak: 0.17 ± 0.12 vs. 0.37 ± 0.098 mMol/l; P < 0.001; time to peak; 151 ± 84 vs. 89 ± 33 minutes; P = 0.007); and both the baseline (8.0 ± 2.1 vs. 5.6 ± 0.23 mMol/l; P < 0.001) and peak (10.0 ± 2.2 vs. 7.7 ± 0.2 mMol/l; P < 0.001) blood glucose levels were higher in patients; compared to healthy subjects. In patients; 3-OMG absorption was directly related to GE (AUC(240); r = -0.77 to -0.87; P < 0.001; peak concentrations; r = -0.75 to -0.81; P = 0.001; time to peak; r = 0.89-0.94; P < 0.001); but when GE was normal (percent retention(240 )< 10%; n = 9) absorption was still impaired. GE was inversely related to baseline blood glucose, such that elevated levels were associated with slower GE (ret 60, 180 and 240 minutes: r > 0.51; P < 0.05). CONCLUSIONS: In critically ill patients; (i) the rate and extent of glucose absorption are markedly reduced; (ii) GE is a major determinant of the rate of absorption, but does not fully account for the extent of impaired absorption; (iii) blood glucose concentration could be one of a number of factors affecting GE. BioMed Central 2009 2009-08-27 /pmc/articles/PMC2750198/ /pubmed/19712450 http://dx.doi.org/10.1186/cc8021 Text en Copyright ©2009 Chapman et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Chapman, Marianne J
Fraser, Robert JL
Matthews, Geoffrey
Russo, Antonietta
Bellon, Max
Besanko, Laura K
Jones, Karen L
Butler, Ross
Chatterton, Barry
Horowitz, Michael
Glucose absorption and gastric emptying in critical illness
title Glucose absorption and gastric emptying in critical illness
title_full Glucose absorption and gastric emptying in critical illness
title_fullStr Glucose absorption and gastric emptying in critical illness
title_full_unstemmed Glucose absorption and gastric emptying in critical illness
title_short Glucose absorption and gastric emptying in critical illness
title_sort glucose absorption and gastric emptying in critical illness
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750198/
https://www.ncbi.nlm.nih.gov/pubmed/19712450
http://dx.doi.org/10.1186/cc8021
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