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Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

OBJECTIVE: We showed that 17β-estradiol (E(2)) favors pancreatic β-cell survival via the estrogen receptor-α (ERα) in mice. E(2) activates nuclear estrogen receptors via an estrogen response element (ERE). E(2) also activates nongenomic signals via an extranuclear form of ERα and the G protein–coupl...

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Detalles Bibliográficos
Autores principales:	Liu, Suhuan, Le May, Cedric, Wong, Winifred P.S., Ward, Robert D., Clegg, Deborah J., Marcelli, Marco, Korach, Kenneth S., Mauvais-Jarvis, Franck
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750222/ https://www.ncbi.nlm.nih.gov/pubmed/19587358 http://dx.doi.org/10.2337/db09-0257

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