Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo

OBJECTIVE: Noninvasive determination of pancreatic β-cell mass in vivo has been hampered by the lack of suitable β-cell–specific imaging agents. This report outlines an approach for the development of novel ligands homing selectively to islet cells in vivo. RESEARCH DESIGN AND METHODS: To generate a...

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Detalles Bibliográficos
Autores principales: Ueberberg, Sandra, Meier, Juris J., Waengler, Carmen, Schechinger, Wolfgang, Dietrich, Johannes W., Tannapfel, Andrea, Schmitz, Inge, Schirrmacher, Ralf, Köller, Manfred, Klein, Harald H., Schneider, Stephan
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750237/
https://www.ncbi.nlm.nih.gov/pubmed/19592622
http://dx.doi.org/10.2337/db09-0658

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