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Theoretical Characterization of Substrate Access/Exit Channels in the Human Cytochrome P450 3A4 Enzyme: Involvement of Phenylalanine Residues in the Gating Mechanism
[Image: see text] The human cytochrome P450 3A4 mono-oxygenates ∼50% of all drugs. Its substrates/products enter/leave the active site by access/exit channels. Here, we perform steered molecular dynamics simulations, pulling the products temazepam and testosterone-6βOH out of the P450 3A4 enzyme in...
Autores principales: | Fishelovitch, Dan, Shaik, Sason, Wolfson, Haim J., Nussinov, Ruth |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750738/ https://www.ncbi.nlm.nih.gov/pubmed/19728720 http://dx.doi.org/10.1021/jp810386z |
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