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COMMD1 Promotes pVHL and O(2)-Independent Proteolysis of HIF-1α via HSP90/70

BACKGROUND: The Copper Metabolism MURR1 Domain containing 1 protein COMMD1 has been associated with copper homeostasis, NF-κB signaling, and sodium transport. Recently, we identified COMMD1 as a novel protein in HIF-1 signaling. Mouse embryos deficient for Commd1 have increased expression of hypoxia...

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Detalles Bibliográficos
Autores principales:	van de Sluis, Bart, Groot, Arjan J., Vermeulen, Jeroen, van der Wall, Elsken, van Diest, Paul J., Wijmenga, Cisca, Klomp, Leo W., Vooijs, Marc
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750754/ https://www.ncbi.nlm.nih.gov/pubmed/19802386 http://dx.doi.org/10.1371/journal.pone.0007332

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