An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor

Kinesin-5 (also known as Eg5, KSP and Kif11) is required for assembly of a bipolar mitotic spindle. Small molecule inhibitors of Kinesin-5, developed as potential anti-cancer drugs, arrest cell in mitosis and promote apoptosis of cancer cells. We performed a genome-wide siRNA screen for enhancers an...

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Detalles Bibliográficos
Autores principales: Tsui, Melody, Xie, Tiao, Orth, James D., Carpenter, Anne E., Rudnicki, Stewart, Kim, Suejong, Shamu, Caroline E., Mitchison, Timothy J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752188/
https://www.ncbi.nlm.nih.gov/pubmed/19802393
http://dx.doi.org/10.1371/journal.pone.0007339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752188/
https://www.ncbi.nlm.nih.gov/pubmed/19802393
http://dx.doi.org/10.1371/journal.pone.0007339

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