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Targeted disruption of cocaine-activated accumbens neurons prevents context-specific sensitization

Learned associations between effects of abused drugs and the drug administration environment play important roles in drug addiction. Histochemical and electrophysiological studies suggest that these associations are encoded in sparsely distributed nucleus accumbens neurons that are selectively activ...

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Detalles Bibliográficos
Autores principales: Koya, Eisuke, Golden, Sam A., Harvey, Brandon K., Guez, Danielle H., Berkow, Alexander, Simmons, Danielle E., Bossert, Jennifer M., Nair, Sunila G., Uejima, Jamie L., Marin, Marcelo T., Mitchell, Timothy, Farquhar, David, Ghosh, Sukhen, Mattson, Brandi J., Hope, Bruce T.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752202/
https://www.ncbi.nlm.nih.gov/pubmed/19620976
http://dx.doi.org/10.1038/nn.2364
Descripción
Sumario:Learned associations between effects of abused drugs and the drug administration environment play important roles in drug addiction. Histochemical and electrophysiological studies suggest that these associations are encoded in sparsely distributed nucleus accumbens neurons that are selectively activated by drugs and drug-associated cues. Although correlations between accumbens neuronal activity and responsivity to drugs and drug cues have been observed, no technique exists for selectively manipulating these activated neurons and establishing their causal role in behavioral effects of drugs and drug cues. Here we describe a novel method, termed ‘Daun02-inactivation method’, that selectively inactivates a minority of neurons activated by cocaine in an environment repeatedly paired with cocaine to demonstrate a causal role for these activated neurons in context-specific cocaine-induced psychomotor sensitization in rats. This method provides a new tool to study causal roles of selectively activated neurons in behavioral effects of drugs and drug cues and in other learned behaviors.