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Quantification of mitochondrial DNA mutation load

Mitochondrial DNA (mtDNA) mutations are an important cause of genetic disease and have been proposed to play a role in the ageing process. Quantification of total mtDNA mutation load in ageing tissues is difficult as mutational events are rare in a background of wild-type molecules, and detection of...

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Detalles Bibliográficos
Autores principales:	Greaves, Laura C, Beadle, Nina E, Taylor, Geoffrey A, Commane, Daniel, Mathers, John C, Khrapko, Konstantin, Turnbull, Doug M
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2009
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752485/ https://www.ncbi.nlm.nih.gov/pubmed/19624578 http://dx.doi.org/10.1111/j.1474-9726.2009.00505.x

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