Cargando…
The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor
Complement 1 (C1) inhibitor is an acute phase protein with anti-inflammatory properties. The aim of the present study was to elucidate the relationship between brachial ankle pulse wave velocity (baPWV), the parameter of arterial stiffness, and C1 inhibitor. One hundred subjects were randomly enroll...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752764/ https://www.ncbi.nlm.nih.gov/pubmed/19794979 http://dx.doi.org/10.3346/jkms.2009.24.5.831 |
_version_ | 1782172298213588992 |
---|---|
author | Chae, Yong Min Park, Jong Kwon |
author_facet | Chae, Yong Min Park, Jong Kwon |
author_sort | Chae, Yong Min |
collection | PubMed |
description | Complement 1 (C1) inhibitor is an acute phase protein with anti-inflammatory properties. The aim of the present study was to elucidate the relationship between brachial ankle pulse wave velocity (baPWV), the parameter of arterial stiffness, and C1 inhibitor. One hundred subjects were randomly enrolled in this study. Data about baPWV, age, gender, hypertension, smoking, and body mass index (BMI) were measured. Blood tests for total cholesterol, low density lipoprotein, high density lipoprotein, triglycerides, hemoglobin A1c, erythrocyte sedimentation rate, C-reactive protein, complement 3, and C1 inhibitor were performed. Based on the Pearson correlation, the C1 inhibitor showed a positive relation to the baPWV (P<0.001). Multiple regression analysis revealed the significant predictors of baPWV were not only the conventional risk factors of arteriosclerosis and/or atherosclerosis, such as age (P<0.001), gender (P<0.001), hypertension (P<0.001), and BMI (P=0.006), but also the acute phase protein, C1 inhibitor (P=0.025). In conclusion, C1 inhibitor is associated with arterial stiffness through its association with increased inflammation. |
format | Text |
id | pubmed-2752764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27527642009-10-01 The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor Chae, Yong Min Park, Jong Kwon J Korean Med Sci Original Article Complement 1 (C1) inhibitor is an acute phase protein with anti-inflammatory properties. The aim of the present study was to elucidate the relationship between brachial ankle pulse wave velocity (baPWV), the parameter of arterial stiffness, and C1 inhibitor. One hundred subjects were randomly enrolled in this study. Data about baPWV, age, gender, hypertension, smoking, and body mass index (BMI) were measured. Blood tests for total cholesterol, low density lipoprotein, high density lipoprotein, triglycerides, hemoglobin A1c, erythrocyte sedimentation rate, C-reactive protein, complement 3, and C1 inhibitor were performed. Based on the Pearson correlation, the C1 inhibitor showed a positive relation to the baPWV (P<0.001). Multiple regression analysis revealed the significant predictors of baPWV were not only the conventional risk factors of arteriosclerosis and/or atherosclerosis, such as age (P<0.001), gender (P<0.001), hypertension (P<0.001), and BMI (P=0.006), but also the acute phase protein, C1 inhibitor (P=0.025). In conclusion, C1 inhibitor is associated with arterial stiffness through its association with increased inflammation. The Korean Academy of Medical Sciences 2009-10 2009-09-23 /pmc/articles/PMC2752764/ /pubmed/19794979 http://dx.doi.org/10.3346/jkms.2009.24.5.831 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chae, Yong Min Park, Jong Kwon The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title | The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title_full | The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title_fullStr | The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title_full_unstemmed | The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title_short | The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor |
title_sort | relationship between brachial ankle pulse wave velocity and complement 1 inhibitor |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752764/ https://www.ncbi.nlm.nih.gov/pubmed/19794979 http://dx.doi.org/10.3346/jkms.2009.24.5.831 |
work_keys_str_mv | AT chaeyongmin therelationshipbetweenbrachialanklepulsewavevelocityandcomplement1inhibitor AT parkjongkwon therelationshipbetweenbrachialanklepulsewavevelocityandcomplement1inhibitor AT chaeyongmin relationshipbetweenbrachialanklepulsewavevelocityandcomplement1inhibitor AT parkjongkwon relationshipbetweenbrachialanklepulsewavevelocityandcomplement1inhibitor |