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Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry

OBJECTIVE: LDL cholesterol <2.80 mmol/l was associated with increased cancer risk in type 2 diabetes. We explored the 1) interaction between low LDL cholesterol and albuminuria and 2) interaction between copresence of these two risk factors and statin use for cancer in type 2 diabetes. RESEARCH D...

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Autores principales: Yang, Xilin, So, Wing Yee, Ma, Ronald C.W., Ko, Gary T.C., Kong, Alice P.S., Zhao, Hailu, Luk, Andrea O.Y., Lam, Christopher W.K., Ho, Chung Shun, Tong, Peter C.Y., Chan, Juliana C.N.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752941/
https://www.ncbi.nlm.nih.gov/pubmed/19592629
http://dx.doi.org/10.2337/dc09-0725
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author Yang, Xilin
So, Wing Yee
Ma, Ronald C.W.
Ko, Gary T.C.
Kong, Alice P.S.
Zhao, Hailu
Luk, Andrea O.Y.
Lam, Christopher W.K.
Ho, Chung Shun
Tong, Peter C.Y.
Chan, Juliana C.N.
author_facet Yang, Xilin
So, Wing Yee
Ma, Ronald C.W.
Ko, Gary T.C.
Kong, Alice P.S.
Zhao, Hailu
Luk, Andrea O.Y.
Lam, Christopher W.K.
Ho, Chung Shun
Tong, Peter C.Y.
Chan, Juliana C.N.
author_sort Yang, Xilin
collection PubMed
description OBJECTIVE: LDL cholesterol <2.80 mmol/l was associated with increased cancer risk in type 2 diabetes. We explored the 1) interaction between low LDL cholesterol and albuminuria and 2) interaction between copresence of these two risk factors and statin use for cancer in type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed prospective data for 3,793 Chinese type 2 diabetic patients who remained naive for statin treatment and 1,483 patients in whom statin treatment was initiated during a median follow-up period of 5.24 years. All patients were free of cancer at baseline. Biological interactions were estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). RERI > 0, AP > 0, or S > 1 indicates biological interaction. RESULTS: In 3,793 statin-naive type 2 diabetic patients, copresence of low LDL cholesterol and albuminuria increased cancer risk by 2.8-fold (hazard ratio 2.77 [95% CI 1.78–4.31]) with significant biological interactions (RERI 1.05 [0.04–2.06]; AP 0.38 [0.09–0.66]). In the whole cohort of 5,276 type 2 diabetic patients, there was interaction between nonuse of statins and copresence of low LDL cholesterol and albuminuria with increased cancer risk (RERI 2.87 [0.64–5.09] and AP 0.60 [0.29–0.90]). Statin nonusers with LDL cholesterol <2.80 mmol/l and albumunuria had a 4.9-fold risk of cancer compared with statin users with or without both risk factors. CONCLUSIONS: In type 2 diabetes, there was interaction between low LDL cholesterol and albuminuria with increased cancer risks. The latter was attenuated in the presence of statin treatment.
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spelling pubmed-27529412010-10-01 Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry Yang, Xilin So, Wing Yee Ma, Ronald C.W. Ko, Gary T.C. Kong, Alice P.S. Zhao, Hailu Luk, Andrea O.Y. Lam, Christopher W.K. Ho, Chung Shun Tong, Peter C.Y. Chan, Juliana C.N. Diabetes Care Original Research OBJECTIVE: LDL cholesterol <2.80 mmol/l was associated with increased cancer risk in type 2 diabetes. We explored the 1) interaction between low LDL cholesterol and albuminuria and 2) interaction between copresence of these two risk factors and statin use for cancer in type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed prospective data for 3,793 Chinese type 2 diabetic patients who remained naive for statin treatment and 1,483 patients in whom statin treatment was initiated during a median follow-up period of 5.24 years. All patients were free of cancer at baseline. Biological interactions were estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). RERI > 0, AP > 0, or S > 1 indicates biological interaction. RESULTS: In 3,793 statin-naive type 2 diabetic patients, copresence of low LDL cholesterol and albuminuria increased cancer risk by 2.8-fold (hazard ratio 2.77 [95% CI 1.78–4.31]) with significant biological interactions (RERI 1.05 [0.04–2.06]; AP 0.38 [0.09–0.66]). In the whole cohort of 5,276 type 2 diabetic patients, there was interaction between nonuse of statins and copresence of low LDL cholesterol and albuminuria with increased cancer risk (RERI 2.87 [0.64–5.09] and AP 0.60 [0.29–0.90]). Statin nonusers with LDL cholesterol <2.80 mmol/l and albumunuria had a 4.9-fold risk of cancer compared with statin users with or without both risk factors. CONCLUSIONS: In type 2 diabetes, there was interaction between low LDL cholesterol and albuminuria with increased cancer risks. The latter was attenuated in the presence of statin treatment. American Diabetes Association 2009-10 2009-07-10 /pmc/articles/PMC2752941/ /pubmed/19592629 http://dx.doi.org/10.2337/dc09-0725 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Yang, Xilin
So, Wing Yee
Ma, Ronald C.W.
Ko, Gary T.C.
Kong, Alice P.S.
Zhao, Hailu
Luk, Andrea O.Y.
Lam, Christopher W.K.
Ho, Chung Shun
Tong, Peter C.Y.
Chan, Juliana C.N.
Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title_full Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title_fullStr Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title_full_unstemmed Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title_short Low LDL Cholesterol, Albuminuria, and Statins for the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
title_sort low ldl cholesterol, albuminuria, and statins for the risk of cancer in type 2 diabetes: the hong kong diabetes registry
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752941/
https://www.ncbi.nlm.nih.gov/pubmed/19592629
http://dx.doi.org/10.2337/dc09-0725
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