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The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria and peroxisomes. To understand the in vivo function of Drp1, complete and tissue-specific mouse knockouts of Drp1 were generated. Drp1-null mice die by embryonic day 11.5. This embryonic lethality is not likely c...

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Detalles Bibliográficos
Autores principales:	Wakabayashi, Junko, Zhang, Zhongyan, Wakabayashi, Nobunao, Tamura, Yasushi, Fukaya, Masahiro, Kensler, Thomas W., Iijima, Miho, Sesaki, Hiromi
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753156/ https://www.ncbi.nlm.nih.gov/pubmed/19752021 http://dx.doi.org/10.1083/jcb.200903065

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