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Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver
BACKGROUND: The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepatic and systemic hemodynamics in rats. METHODS: He...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753560/ https://www.ncbi.nlm.nih.gov/pubmed/19765284 http://dx.doi.org/10.1186/1471-230X-9-69 |
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author | Halverscheid, Leonie Deibert, Peter Schmidt, René Blum, Hubert E Dunkern, Torsten Pannen, Benedikt HJ Kreisel, Wolfgang |
author_facet | Halverscheid, Leonie Deibert, Peter Schmidt, René Blum, Hubert E Dunkern, Torsten Pannen, Benedikt HJ Kreisel, Wolfgang |
author_sort | Halverscheid, Leonie |
collection | PubMed |
description | BACKGROUND: The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepatic and systemic hemodynamics in rats. METHODS: Hemodynamic parameters were monitored for 60 min. after intravenous injection of sildenafil and vardenafil [1, 10 and 100 μg/kg (sil1, sil10, sil100, var1, var10, var100)] in anesthetized rats. RESULTS: Cardiac output and heart rate remained constant. After a short dip, mean arterial blood pressure again increased. Systemic vascular resistance transiently decreased slightly. Changes in hepatic hemodynamic parameters started after few minutes and continued for at least 60 min. Portal (var10 -31%, sil10 -34%) and hepatic arterial resistance (var10 -30%, sil10 -32%) decreased significantly (p < 0.05). At the same time portal venous (var10 +29%, sil10 +24%), hepatic arterial (var10 +34%, sil10 +48%), and hepatic parenchymal blood flow (var10 +15%, sil10 +15%) increased significantly (p < 0.05). The fractional liver blood flow (total liver flow/cardiac output) increased significantly (var10 26%, sil10 23%). Portal pressure remained constant or tended to decrease. 10 μg/kg was the most effective dose for both PDE-5 inhibitors. CONCLUSION: Low doses of phosphodiesterase-5 inhibitors have distinct effects on hepatic hemodynamic parameters. Their therapeutic use in portal hypertension should therefore be evaluated. |
format | Text |
id | pubmed-2753560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27535602009-09-29 Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver Halverscheid, Leonie Deibert, Peter Schmidt, René Blum, Hubert E Dunkern, Torsten Pannen, Benedikt HJ Kreisel, Wolfgang BMC Gastroenterol Research Article BACKGROUND: The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepatic and systemic hemodynamics in rats. METHODS: Hemodynamic parameters were monitored for 60 min. after intravenous injection of sildenafil and vardenafil [1, 10 and 100 μg/kg (sil1, sil10, sil100, var1, var10, var100)] in anesthetized rats. RESULTS: Cardiac output and heart rate remained constant. After a short dip, mean arterial blood pressure again increased. Systemic vascular resistance transiently decreased slightly. Changes in hepatic hemodynamic parameters started after few minutes and continued for at least 60 min. Portal (var10 -31%, sil10 -34%) and hepatic arterial resistance (var10 -30%, sil10 -32%) decreased significantly (p < 0.05). At the same time portal venous (var10 +29%, sil10 +24%), hepatic arterial (var10 +34%, sil10 +48%), and hepatic parenchymal blood flow (var10 +15%, sil10 +15%) increased significantly (p < 0.05). The fractional liver blood flow (total liver flow/cardiac output) increased significantly (var10 26%, sil10 23%). Portal pressure remained constant or tended to decrease. 10 μg/kg was the most effective dose for both PDE-5 inhibitors. CONCLUSION: Low doses of phosphodiesterase-5 inhibitors have distinct effects on hepatic hemodynamic parameters. Their therapeutic use in portal hypertension should therefore be evaluated. BioMed Central 2009-09-18 /pmc/articles/PMC2753560/ /pubmed/19765284 http://dx.doi.org/10.1186/1471-230X-9-69 Text en Copyright ©2009 Halverscheid et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Halverscheid, Leonie Deibert, Peter Schmidt, René Blum, Hubert E Dunkern, Torsten Pannen, Benedikt HJ Kreisel, Wolfgang Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title | Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title_full | Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title_fullStr | Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title_full_unstemmed | Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title_short | Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
title_sort | phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753560/ https://www.ncbi.nlm.nih.gov/pubmed/19765284 http://dx.doi.org/10.1186/1471-230X-9-69 |
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