Lysyl Oxidase Pro-peptide Inhibits Prostate Cancer Cell Growth by Mechanisms that Target FGF-2-Cell Binding and Signaling

Enhanced RAS signaling and decreased androgen dependence of prostate cancer cells accompany poor clinical outcomes. Elevated autocrine FGF-2 signaling promotes prostate cancer cell growth and survival. Expression of lysyl oxidase (LOX) inhibits RAS transforming activity. LOX is secreted as 50 kDa pr...

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Detalles Bibliográficos
Autores principales: Palamakumbura, Amitha H., Vora, Siddharth R., Nugent, Matthew A., Kirsch, Kathrin H., Sonenshein, Gail E., Trackman, Philip C.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753565/
https://www.ncbi.nlm.nih.gov/pubmed/19597471
http://dx.doi.org/10.1038/onc.2009.203

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